Further to my last post here is a picture diary describing exactly how the Old School Press made their first book - "The Bricks of Venice" by John Ruskin = http://www.theoldschoolpress.com/osppic/ospatwork/makingBOV1.htm.
The image below is one of the first pages of chapter 3, Crenellations. It has some large Bembo italic for the chapter number and title.